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SEN 1269
CAS No. 956128-01-1
SEN 1269 ( SEN1269 )
产品货号. M16823 CAS No. 956128-01-1
SEN1269 是一种新型有效的 Aβ 聚集抑制剂，可与单体 Aβ1-42 结合，Kd 为 4.4 uM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥7857 | 有现货 |
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| 50MG | ￥16038 | 有现货 |
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| 100MG | ￥20250 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称SEN 1269
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述SEN1269 是一种新型有效的 Aβ 聚集抑制剂，可与单体 Aβ1-42 结合，Kd 为 4.4 uM。
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产品描述SEN1269 is a novel potent Aβ aggregation inhibitor that binds to monomeric Aβ1-42 with Kd of 4.4 uM, protects neuronal cell lines against an Aβ1-42 insult with IC50 of 15 uM; produces a concentration-related blockade of Aβ(1-42) aggregation and protects neuronal cell lines exposed to Aβ(1-42); alleviates deficits in hippocampal LTP induced by Aβ(1-42) and cell-derived Aβ oligomers; reduces Aβ-induced neurotoxicity and shows neuroprotective in behavioural models of memory relevant to Aβ-induced neurodegeneration.
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体外实验——
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体内实验——
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同义词SEN1269
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通路Others
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靶点Amyloids
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受体Amyloids
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研究领域——
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适应症——
化学信息
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CAS Number956128-01-1
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分子量322.368
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分子式C18H18N4O2
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纯度>98% (HPLC)
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溶解度——
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SMILESOC1=CC=CC(NC2=NC=C(OC3=CC=CC(N(C)C)=C3)C=N2)=C1
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化学全称3-((5-(3-(dimethylamino)phenoxy)pyrimidin-2-yl)amino)phenol
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Scopes DI, et al. Br J Pharmacol. 2012 Sep;167(2):383-92.
